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KMID : 0379520090250010029
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한국독성학회지
2009 Volume.25 No. 1 p.29 ~ p.33
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Hepatoprotective Effects of Polysaccharides Isolated from Phellinus gilvus Against Carbon Tetrachloride-induced Liver Injury in Rats
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Park Seung-Chun
Song Jae-Chan
Kim Kil-Soo
Kim Tae-Wan
Rhee Man-Hee
Cheon Yong-Pil
Son Wha-Young
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Abstract
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Phellinus gilvus (PG) is a widely used mushroom for health promotion. We studied the hepatoprotective effect of the polysaccharide aqueous extract of PG (PGP) against carbon tetrachloride ()-induced liver injury in rats. Sprague Dawley rats were divided into 5 groups: Normal control, control, PGP 50, 100, and 200 mg/kg + . The levels of serum biochemical parameters, liver lipid peroxide and antioxidant enzymes, and histological appearances were evaluated. The -induced increments of alanine aminotransferase, asparate aminotransferase, and alkaline phosphatase levels in serum were significantly decreased by PGP-pretreatments. The PGP dose-dependently decreased hepatic malondialdehyde formations in -treatment groups. Hepatic antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) were elevated by PGP in -treatment groups. Histopathological evaluation of liver showed that the loss of hepatocytes, fatty changes, swelling and extensive necrosis of hepatocytes in centrilobular regions of the -treated rats were ameliorated by PGP pretreatment. The PGP has hepatoprotective and antioxidative effects in -induced liver injury of rat.
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KEYWORD
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Phellinus gilvus polysaccharide, Carbon tetrachloride, Hepatoprotective effect
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